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. 2017 Apr 13;113(7):795–804. doi: 10.1093/cvr/cvx072

Figure 2.

Figure 2

Inhibition of PKCα abolishes the vascular effects of LAV-BPIFB4. Dose–response curves to ACh in ex vivo C57BL/6 mouse mesenteric arteries transfected with (A) an empty vector or (B) a vector for the expression of LAV-BPIFB4, with and without the PKCα inhibitor Gö6976. Values are means ± S.E.M., n = 10 experiments per group. Statistics was performed using two-way ANOVA; **P < 0.01. (C) Western blot of transfected, ex vivo C57BL/6 mouse mesenteric arteries. Right graphs show quantification of p-eNOS (S1177), p-PKCα (T497), p-BPIFB4 (S75), and BPIFB4. Values are means ± S.E.M., n = 6 experiments. Statistics was performed using one-way ANOVA, following Bonferroni’s Multiple Comparison Test; *P < 0.05. E, empty vector; LAV, vector for the expression of LAV-BPIFB4; Gö6976, PKCα inhibitor.