Fig. 5.

JTD reduces the accumulation of AGEs and RAGE. a Immunohistochemistry of AGEs (original magnification ×400); b immunohistochemistry of RAGE (original magnification ×400); c JTD reduces the ratio of the area with AGEs accumulation to the total glomerular area; d JTD reduces the ratio of the area with RAGE accumulation to the total glomerular area; g Western blot analysis of AGEs and RAGE; h JTD can down-regulate the expression of AGEs; i JTD can down-regulate the expression of RAGE. Data are expressed as the mean ± S.D.; N = 10; *P < 0.05; **P < 0.01; and ***P < 0.001 compared to the model group