Table 1.
Efficacy of topical imidacloprid + moxidectin combined with oral doxycycline against transplanted adult Dirofilaria immitis. Adult heartworm recovery from necropsy for the control and treated groups. Necropsy was performed on study days 278–282, 10 months post-treatment
| Group | Animal ID | No. of male worms recovered | No. of female worms recovered | Totala |
|---|---|---|---|---|
| Control | 43493 | 3 | 7 | 10 |
| 43491 | 4 | 6 | 10 | |
| 43486 | 5 | 6 | 11 | |
| 43481 | 5 | 6 | 11 | |
| 43492 | 3 | 7 | 10 | |
| 43480 | 5 | 7 | 12 | |
| 43489 | 4 | 6 | 10 | |
| 43484 | 4 | 7 | 11 | |
| Geometric mean | 10.6b | |||
| Arithmetic mean ± SD | 10.625 ± 0.74 | |||
| Advantage Multi + Doxycycline Treated | 43495 | 0 | 2 | 2 |
| 43494 | 0 | 0 | 0 | |
| 43485 | 0 | 1 | 1 | |
| 43482 | 0 | 0 | 0 | |
| 43483 | 1 | 1 | 2 | |
| 43490 | 0 | 0 | 0 | |
| 43488 | 0 | 0 | 0 | |
| 43487 | 0 | 0 | 0 | |
| Geometric mean | 0.44b | |||
| Arithmetic mean ± SD | 0.625 ± 0.92 | |||
| Treatment percent efficacy | 95.9 | |||
aTotal worm counts include intact worms plus non-degenerate fragments. Only 1 was added to the total worm number if non-degenerate fragments could not be identified as distinct worms
bThe average recovery of adult worms for each group was calculated using the geometric mean of each group