Fig. 5.

Simulation of anemia of chronic disease. The model calibrated for the adequate iron diet was used (#6 in Table 2). At time zero the hepcidin level was increased five-fold and maintained at that level for 365 days. The abscissa represents concentration and the ordinate the time. a plasma, (b) duodenum, (c) bone marrow, (d) red blood cells, (e) liver, (f) spleen, (g) rest of body, and (h) hepcidin