Figure 3.

Gentamicin and novobiocin combined with sub-MIC antibiotics can reduce ermC transduction. Combination of gentamicin (a and c) or novobiocin (b and d) with sub-inhibitory combinations of antibiotics, without (a and b) or with (c and d) UV light. Combinations of antibiotics are indicated by hatching. Gentamicin reduced the transfer induced by ciprofloxacin and mupirocin. In the presence of UV light, both gentamicin and novobiocin reduced the high-level transfer induced by cefoxitin and trimethoprim, as well as reducing the transfer induced by all the remaining antibiotics tested. Mean of at least three experiments in triplicate (±SD). *P < 0.05, **P < 0.01, ***P < 0.001. Lytic phage was also inhibited (Figure S1). This figure appears in colour in the online version of JAC and in black and white in the print version of JAC.