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. 2017 May 18;14:14. doi: 10.1186/s12987-017-0063-4

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Albumin (a) and IgG (b) quotient distributions in the spinal cerebrospinal fluid. x is the normalized location on the rostro-caudal axis from lumbar (x = 0) to cervical space (x = 1) as illustrated in Fig. 3a. Quotients are obtained using spinal CSF drainage rates calculated as outlined in the “Methods” section. Permeability of the blood-CNS barrier to IgG is obtained using Eq. (7)