Table 5.
Antioxidant enzyme activities in liver tissue of APAP- treated rats, SOD (U/g tissue) and CAT (U/g tissue)
| Treatment | Dose (mg/kg) | SOD (U/g tissue) |
CAT (U/g tissue) |
GSH (μM/mg protein) |
|---|---|---|---|---|
| Normal | - | 9.66 ± 0.38 | 114.80 ± 1.63 | 68.32 ± 1.19 |
| 10% DMSO + APAP | - | 3.99 ± 0.07a | 91.36 ± 1.27a | 29.77 ± 0.47 |
| Silymarin + APAP | 200 | 15.37 ± 0.35b | 109.50 ± 4.69b | 59.44 ± 0.95 |
| MEDL + APAP | 50 | 13.04 ± 0.16b | 115.40 ± 2.37b | 38.12 ± 0.71 |
| 250 | 11.29 ± 0.13b | 120.30 ± 1.09b | 53.11 ± 1.05 | |
| 500 | 11.57 ± 0.33b | 118.2 ± 0.81b | 63.83 ± 2.03 |
Values are expressed as means ± S.E.M. of six replicates
aSignificant different as compared to normal control, P < 0.05
bSignificant different as compared to negative control (10% DMSO + APAP), P < 0.05