Table 2.
Association between TSH categories and hip or knee replacement due to osteoarthritis
| TSH (mU/L) | Persons (n) | Cases (n) | HRa | (95% CI) | HRb | (95% CI) | HRc | (95% CI) |
|---|---|---|---|---|---|---|---|---|
| THR | ||||||||
| < 0.50 | 908 | 21 | 0.98 | (0.63–1.53) | 0.99 | (0.64–1.53) | 1.04 | (0.63–1.69) |
| 0.50–1.49 | 17675 | 411 | 0.93 | (0.81–1.08) | 1.07 | (0.93–1.24) | 1.09 | (0.94–1.28) |
| 1.5–2.49 | 13228 | 359 | 1 | Reference | 1 | Reference | 1 | Reference |
| 2.5–3.49 | 3773 | 105 | 0.98 | (0.79–1.22) | 0.85 | (0.68–1.05) | 0.88 | (0.69–1.11) |
| > 3.5 | 2307 | 82 | 1.22 | (0.96–1.55) | 0.96 | (0.76–1.22) | 0.98 | (0.75–1.27) |
| TKR | ||||||||
| < 0.50 | 908 | 14 | 1.26 | (0.73–2.16) | 1.32 | (0.76–2.26) | 1.33 | (0.74–2.4) |
| 0.50–1.49 | 17675 | 224 | 0.97 | (0.80–1.18) | 1.15 | (0.95–1.40) | 1.12 | (0.91–1.37) |
| 1.5–2.49 | 13228 | 191 | 1 | Reference | 1 | Reference | 1 | Reference |
| 2.5–3.49 | 3773 | 64 | 1.12 | (0.84–1.48) | 0.94 | (0.71–1.25) | 0.88 | (0.65–1.20) |
| > 3.5 | 2307 | 45 | 1.24 | (0.90–1.72) | 0.98 | (0.70–1.35) | 0.87 | (0.61–1.25) |
(THR total hip replacement, TKR total knee replacement)
aUnadjusted
bAdjusted for age, sex, BMI and smoking
cAdjusted for age, sex, BMI, smoking, physical activity and diabetes