Table 3.
Hepatitis C virus-RNA and patient liver enzyme status for the 8 included studies
| Ref. |
HCV-RNA |
Liver enzyme level |
|||||
|
High viral load |
Low viral load |
All patients | AST | ALT | |||
| n | Limit | n | Limit | ||||
| Apolinario et al[9] | 28 | ≥ 6.3 log IU/mL5 | 35 | < 6.3 log IU/mL5 | 118 IU/L (± 64) $ | ||
| 1Lagging et al[34] | |||||||
| IL28B rs12979860 CC | 6.3 log IU/mL (± 0.8)3 | Information not provided | |||||
| IL28B rs12979860 CT | 6.1 log IU/mL (± 0.7)3 | ||||||
| IL28B rs12979860 TT | 5.9 log IU/mL (± 0.8)3 | ||||||
| Diago et al[7] | 85 | ≥ 5.7 log IU/mL5 | 52 | < 5.7 log IU/mL5 | 117.2 IU/L (± 81.6)3 | ||
| Fattovich et al[21] | 147 | ≥ 5.6 log IU/mL5 | 5.74 log IU/mL (± 0.9)35 | 92 IU/L (± 78)3 | |||
| Kurelac et al[33] | 5.55 log IU/mL (5.52-6.1)25 | Information not provided | |||||
| Darling et al[31] | 6.66 log IU/mL (± 6.76)35 | 90.9 IU/L (72.9)3 | |||||
| Darbala et al[32] | 4.95 log IU/mL (3.6-5.63)45 | 38 IU/L (27-51)4 | 51 IU/L (34-87)4 | ||||
| Al-Ashgar et al[19] | 45 | ≥ 5.78 log IU/mL | 19 | < 5.78 log IU/mL5 | 67.5 IU/L (43.5-106.8)2 | 56.0 IU/L (32.0-86.0)2 | |
1
Lagging et al provided baseline demographics in accordance with IL-28 genotype (only baseline characteristics for rs12979860 are reported in the review, as these were representative for the study population);
2
Median (25-75 percentiles);
3
Mean (SD);
4
Median (IQR);
5
Recalculated into log IU/mL. HCV-RNA is shown as number of patients with high or low viral load or as the mean or median for the entire population. Depending of the presentation in the original article, levels of ALT, AST or both are shown. HCV: Hepatitis C virus; ALT: Alanine transaminase; AST: Aspartate transaminase.