Table 8.
Overview of sustained viral response in the 8 studies providing information on baseline inducible protein-10’s, and hepatitis C virus-RNA levels 24 wk after end-of- treatment
| Ref. | Patients (n) | IP-10 measurement method | Genotype (n) |
Baseline IP-10 concentration, grouped by sustained virological response (pg/mL) |
Overall SVR |
|||
| SVR | Non-SVR | P-value | SVR | Non-SVR | ||||
| Apolinario et al[9] | 63 | ELISA (OptEIA, Pharmingen, San Diego, CA, United States) | 1 (43) | 245 (± 154) | 381 (± 138) | P < 0.05 (mean ± SD) | 36 | 27 |
| Diago et al[7] | 137 | ELISA (Human immunoassay kit; BioSource Europe SA, Nivelles, Belgium | 1 (103) | 347 (± 197.4) | 500.6 (± 311.2) | P < 0.01 (mean ± SD) | 792 | 582 |
| 1 (103) | 332.4 (± 222.1) | 476.8 (± 305.3) | P < 0.01 (mean ± SD) | |||||
| 2 (9) | ||||||||
| 3 (25) | ||||||||
| 1Fattovich et al[21] | 226 | ELISA (Quantikine, R and D systems, Minneapolis, MN, United States ) | 1 (92) | 2.47 ± 0.23 | 2.65 ± 0.28 | P < 0.001 (log mean ± SD) | 2092 | 712 |
| 2 (87) | 2.37 ± 0.31 | 2.33 ± 0.35 | P > 0.05 (log mean ± SD) | |||||
| 3 (47) | 2.42 ± 0.21 | 2.67 ± 0.46 | P < 0.05a (log mean ± SD) | |||||
| Kurelac et al[33] | 46 | ELISA (Quantikine, R and D systems, Minneapolis, MN, United States ) | 1 (46) | 185 (63-518) | 395.5 (111-926) | P < 0.0001 (median, range) | 26 | 20 |
| Darling et al[31] | 272 | ELISA (Quantikine, R and D systems, Minneapolis, MN, United States ) | 1 (272) | 437 (± 31) | 704 (± 44) | P < 0.001 (mean ± SD) | 157 | 115 |
| Derbala et al[32] | 159 | Luminex, Cytokine multiplex immunoassay kit (Merck Millipore, Billerica, MA, United States) | 4 (159) | Exact data not provided, only graphic presentation | P < 0.001 (median, IQR) | 98 | 61 | |
| Al-Ashgar et al[19] | 64 | ELISA (Quantikine, R andD systems, Minneapolis, MN, United States ) | 4 (64) | 462 (± 282.6) | 840.4 (± 490.6) | P < 0.01 (mean ± SD) | 41 | 23 |
Entire patina population was 280, genotype 4 removed from the analyses, and IP-10 results was available for 226 patients Note that M. Derbala et al did not provide written specification on IP-10 levels for SVR compared to non-SVR, and only supplied a graphic depiction, which could not be interpreted to adequate results;
SVR for the entire population.
P = 0.02. Only the results of statistical tests with a P value < 0.01 were considered of interest, because of the multiple comparisons between subjects with and without SVR. SVR: Sustained viral response; IP-10: Inducible protein-10.