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. 2017 May 19;10:33. doi: 10.1186/s12920-017-0271-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Distribution of sequence coverage. a exons of canonical transcripts of 76 cancer predisposition genes within the MSK-IMPACT panel, b intronic regions flanking targeted exons (50 bp). c Average sequence coverage decreases with increasing distance from the exon-intron boundary (black line), while the fraction of intronic regions flanking the exons that maintain a minimum of 50× coverage (red line) drops off sharply as the size of the flanking regions exceed 100 bp. Dotted line indicates 50 bp