Fig. 4.

XLF knockdown restores drug sensitivity in HCC xenograft model. a Experimental setup used to create the xenograft model. shCon and shXLF 97 L cells (1 × 10⁶) were subcutaneously injected into nude mice. Oxaliplatin (4 mg/kg/week or 10 mg/kg/week) was administered to the mice by intra-peritoneal injection. b Tumor volume was reported in mm³ as the mean ± SD and statistically compared between shCon and shXLF tumors. c Representative images of xenograft tumor. d In vitro NHEJ activity in nuclear proteins extracted from xenograft tumor tissue. The statistical comparison was based on the mean ± SD from 3 independent experiments