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. 2017 May 2;19(5):1056–1067. doi: 10.1016/j.celrep.2017.04.028

Figure 3.

Figure 3

RNA Maps of TDP-43 around Proximal and Distal Same-Exon Poly(A) Sites with iCLIP Clusters

(A) Proximal poly(A) site RNA map of TDP-43 iCLIP at regulated genes. TDP-43 is bound around repressed poly(A) sites and to a lesser extent (sparsely) further upstream and downstream of enhanced poly(A) sites.

(B) Top 20 iCLIP mRNA targets contributing to proximal poly(A) site repression.

(C) Top 20 iCLIP mRNA targets contributing to proximal poly(A) site enhancement.

(D) Distal site RNA map of TDP-43 binding around regulated genes. The level of binding is lower compared to the proximal sites (Table S6).