Motif Analysis around TDP-43-Regulated Same-Exon Poly(A) Sites
Up to two of the most significant motif clusters are shown for each search region (R1, R2, R3).
(A) Motif analysis around proximal poly(A) sites show significant UG-rich clusters in R1 [–100..–40] and R2 [–40..20] around repressed proximal poly(A) sites. The repressive effect concords with TDP-43 iCLIP binding analysis (Figure 3). More distal binding in R3 [20..80] results in enhancement.
(B) Motif analysis around distal poly(A) sites reveals less pronounced regulatory effects, mostly enhancement guided by UC and UA-rich clusters.