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. 2017 May 2;19(5):1022–1032. doi: 10.1016/j.celrep.2017.04.025

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© 2017 The Francis crick Institute

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Viral Genomes Recruit Replisome-Associated RPA2

(A) Immunofluorescence analysis reveals that RPA co-localizes with H5, I3, and E9 on viral genomes in cells infected for 6 hr in the presence of AraC. Scale bars, 20 μm.

(B) Immunoblot analysis of GFP-Trap pull-downs from cells infected for 5 hr with GFP-H5 virus reveals that RPA, but not I3, associates with the viral replisome components E9 and H5.

(C) Immunoblot analysis of GFP-Trap pull-downs performed on lysates from U2-OS-GFP-RPA cells infected for 5 hr with WR reveals that RPA, but not I3, associates with the viral replisome.