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. 2017 Jan 9;36(4):425–440. doi: 10.15252/embj.201694314

Figure 3. Structural model of ubiquitylation‐dependent oligomerization.

Figure 3

  1. In the apo form, α1 (red) blocks the oligomerization interface.
  2. Upon ubiquitylation, the conjugated ubiquitin binds to the HECT‐UBD, and by thus pulls α1 out of the interface and enables oligomerization.
  3. Model of trimeric Ub‐HECT. Three HECT molecules are depicted in various shades of blue, and ubiquitin moieties are represented in orange.
  4. Enlarged view of the HECT:Ub interface including key residues chosen for experimental assessment of the model.