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Multi-step resistance selection of compounds 1, 2, 3, and linezolid against A) vancomycin-resistant Enterococcus faecium HM-968 and B) vancomycin-resistant Enterococcus faecalis ATCC 51299. Bacteria were serially passaged over a fourteen-day period and the broth microdilution assay was used to determine the minimum inhibitory concentration of each compound against VRE after each successive passage. A four-fold shift in the MIC is defined as resistance to the test agent.
