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. Author manuscript; available in PMC: 2018 Mar 23.
Published in final edited form as: J Med Chem. 2017 Mar 15;60(6):2425–2438. doi: 10.1021/acs.jmedchem.6b01780

Figure 8.

Figure 8

Dose response curves for enzyme inhibition by 1, and its effects on the PMF. A, UPPP (YubB) inhibition; bacitracin control. B, UPPS inhibition, bisamidine NSC-50460 control. C, PMF collapse in E. coli IMVs, ATP driven PMF, CCCP control. D, As C but succinate/O2-driven PMF generation.