. Author manuscript; available in PMC: 2018 Mar 23.

Published in final edited form as: J Med Chem. 2017 Mar 15;60(6):2425–2438. doi: 10.1021/acs.jmedchem.6b01780

Table 2.

Minimum inhibitory concentration (MIC₅₀) (in μg/mL) and minimum bactericidal concentration (MBC₅₀) of phenylthiazole compounds 1–3, vancomycin, and linezolid against 50% of vancomycin-sensitive (VSE) and vancomycin-resistant Enterococcus faecalis or E. faecium (VRE) strains.

Bacterial species (number of isolates)	1		2		3		Vancomycin		Linezolid
Bacterial species (number of isolates)	MIC₅₀	MBC₅₀	MIC₅₀	MBC₅₀	MIC₅₀	MBC₅₀	MIC₅₀	MBC₅₀	MIC₅₀	MBC₅₀
Enterococcus faecium (3)	4	4	8	16	4	4	1	–	2	16
Vancomycin-resistant Enterococcus faecium (10)	2	4	1	16	1	4	>64	>64	1	128
Enterococcus faecalis (5)	4	4	8	16	8	8	1	–	1	64
Vancomycin-resistant Enterococcus faecalis (6)	4	4	2	4	4	4	>64	>64	1	64