Figure 5.

Electroencephalographic (EEG) source analysis for target trials. Cortical maps indicate sources for event-related potential (ERP) peak activation during each time window. No difference between schizophrenia patients and healthy comparison participants were observed early time window (P₁; a). Source localization analyses of the middle time window (N₂) indicated significantly greater positive source activity (current source/efferent dipole), in the dorsolateral prefrontal cortex (DLPFC) for healthy participants compared to schizophrenia patients (b). Source localization analyses also indicated greater negative source activity (current sink/afferent dipole) in the right posterior cingulate cortex in the later time window (P₃) for healthy participants compared with schizophrenia patients (c). Source analyses were computed for the 20 ms (10 ms pre and post) surrounding the group-level ERP peak amplitude for that time window. For both N₂ and P₃ windows, healthy participants demonstrated greater source activity compared to schizophrenia patients, with source colors representing dipole direction of significant between group differences. A full color version of this figure is available at the Neuropsychopharmacology journal online.