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. 2017 Jan 4;42(6):1272–1283. doi: 10.1038/npp.2016.273

Figure 6.

Figure 6

Observational fear training (OF) decreases sensitivity to baclofen in somatostatin (SOM) interneurons, but not in parvalbumin (PV) interneurons. (a) Examples of inhibitory postsynaptic currents (IPSCs) evoked in dorso-medial prefrontal cortex (dmPFC) principal neurons by a single pulse of blue light stimulation of PV-interneurons expressing ChR2, before (Baseline, dashed lines) and after 5 min exposure to 20 μM baclofen in the bath (Baclofen, continuous lines) in control (Control: eight cells/three mice) and OF (eight cells/three mice) groups. Averages of 10 sweeps are shown. Arrowheads under each sweep show the time of blue light stimulation. (b) Same as in a for blue light stimulation of SOM interneurons expressing ChR2. Control: 10 cells/3 mice; OF: 9 cells/3 mice. (c) Summary diagram for amplitudes of IPSCs in the presence of baclofen as % of values before baclofen perfusion. *p<0.05. Error bars represent SEM.