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. 2015 Jun 15;3:8–13. doi: 10.5414/CNCS108491

Table 1. Pertinent initial laboratory test results.

Lab test Patient’s result (normal range)
Hemoglobin 6.5 (11.8 – 15.8) g/dL
MCV 96 (80 – 100) fL
Platelets 89 (140 – 440) Thou/uL
AST 35 (0 – 37) U/L
ALT 19 (0 – 40) U/L
ALK PHOS 70 (39 – 117) U/L
LDH 975 (94 – 250) U/L
Haptoglobin < 20 (25 – 200) mg/dL
Blood smear 2 + schistocytes (none expected)
ADAMTS13 75% (50 – 160%)

MCV = mean corpuscular volume; AST = liver enzymes aspartate aminotransferase; ALT = alanine aminotransferase; ALK PHOS = alkaline phosphatase; LDH = lactate dehydrogenase. A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity level was measured with a direct activity assay using Fluorescence Resonance Energy Transfer [FRETS] with the VWF (Von Willebrand Factor) 73 fragment as the substrate. Severe deficiency as in TTP is 5 – 10% activity level.