Table 1. Pertinent initial laboratory test results.
Lab test | Patient’s result (normal range) |
---|---|
Hemoglobin | 6.5 (11.8 – 15.8) g/dL |
MCV | 96 (80 – 100) fL |
Platelets | 89 (140 – 440) Thou/uL |
AST | 35 (0 – 37) U/L |
ALT | 19 (0 – 40) U/L |
ALK PHOS | 70 (39 – 117) U/L |
LDH | 975 (94 – 250) U/L |
Haptoglobin | < 20 (25 – 200) mg/dL |
Blood smear | 2 + schistocytes (none expected) |
ADAMTS13 | 75% (50 – 160%) |
MCV = mean corpuscular volume; AST = liver enzymes aspartate aminotransferase; ALT = alanine aminotransferase; ALK PHOS = alkaline phosphatase; LDH = lactate dehydrogenase. A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) activity level was measured with a direct activity assay using Fluorescence Resonance Energy Transfer [FRETS] with the VWF (Von Willebrand Factor) 73 fragment as the substrate. Severe deficiency as in TTP is 5 – 10% activity level.