Table 3. Traditional multivariable Cox regression for the association of covariates with recurrent depressive disorder.
| Characteristic | HR | 95% CI | P-value |
|---|---|---|---|
| Age (years) | |||
| <50 | 1.0 | ||
| 50–59 | 0.92 | 0.75–1.13 | 0.42 |
| ⩾60 | 0.73 | 0.57–0.93 | 0.010 |
| Sex | |||
| Female | 1.0 | ||
| Male | 1.30 | 1.09–1.55 | 0.0044 |
| Medical diseases | |||
| Diabetes | 0.93 | 0.76–1.15 | 0.52 |
| Hypertension | 1.14 | 0.94–1.39 | 0.19 |
| Hypercholesterolemia | 1.11 | 0.89–1.37 | 0.36 |
| COPD | 1.21 | 0.98–1.49 | 0.074 |
| Coronary heart disease | 0.99 | 0.77–1.27 | 0.93 |
| Liver cirrhosis | 0.95 | 0.77–1.19 | 0.67 |
| Anemia | 0.90 | 0.66–1.23 | 0.52 |
| Thyroid disease | 0.94 | 0.68–1.32 | 0.73 |
| Anxiety disorder | 1.87 | 1.53–2.28 | <0.0001 |
| Zolpidem use | 2.20 | 1.84–2.64 | <0.0001 |
| Past history | |||
| Depressive disorder | 1.53 | 1.17–2.00 | 0.002 |
| Antidepressant use | 1.05 | 0.84–1.30 | 0.70 |
Abbreviations: CI, confidence interval, COPD, chronic obstructive pulmonary disease; HR, hazard ratio.