Table 2. Pathways differentially modulated in subjects exposed to SLEs (P-value<0.05).
| Pathway | Molecules | |
|---|---|---|
| 1 | Role of IL-17A in psoriasis | CXCL8, S100A9, S100A8, CXCL1 |
| 2 | Caveolar-mediated endocytosis signaling | FLNB, FLNA, ABL1, ITGAL, ITGB7 |
| 3 | Natural killer cell signaling | CD247, NCR1, LAT, ZAP70, KIR3DL2, SH2D1B |
| 4 | Tumoricidal function of hepatic natural killer cells | PRF1, GZMB, ITGAL |
| 5 | Virus entry via endocytic pathways | FLNB, FLNA, ABL1, ITGAL, ITGB7 |
| 6 | Cytotoxic T lymphocyte-mediated apoptosis of target cells | CD247, PRF1, GZMB |
| 7 | Superpathway of methionine degradation | FTSJ1, GOT2, AHCY |
| 8 | Role of IL-17F in allergic inflammatory airway diseases | CXCL8, CCL4, CXCL1 |
| 9 | CTLA4 signaling in cytotoxic T lymphocytes | CD247, PPP2R5D, LAT, ZAP70 |
| 10 | Granzyme B signaling | PRF1, GZMB |
| 11 | Crosstalk between dendritic cells and natural killer cells | PRF1, KIR3DL2, ITGAL, IL2RB |
| 12 | Methionine degradation I (to Homocysteine) | FTSJ1, AHCY |
| 13 | Differential regulation of cytokine production in macrophages and T helper cells by IL-17A and IL-17F | CCL4, CXCL1 |
| 14 | T-cell receptor signaling | CD247, PTPRH, LAT, ZAP70 |
| 15 | Cysteine biosynthesis III (mammalia) | FTSJ1, AHCY |
| 16 | Granzyme A signaling | PRF1, HIST1H1E |
| 17 | iCOS-iCOSL signaling in T helper cells | CD247, LAT, ZAP70, IL2RB |
| 18 | Glycine biosynthesis I | SHMT2 |
| 19 | Differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F | CCL4, CXCL1 |
| 20 | TCA cycle II (eukaryotic) | SDHA, ACO1 |
| 21 | IL-17A signaling in gastric cells | CXCL8, CXCL1 |
| 22 | Cell cycle control of chromosomal replication | MCM3, CDK6 |
| 23 | NADH repair | APOA1BP |
| 24 | 5-aminoimidazole ribonucleotide biosynthesis I | GART |
| 25 | Glutamate degradation II and aspartate biosynthesis | GOT2 |
| 26 | Aspartate biosynthesis | GOT2 |
| 27 | EIF2 signaling | RPS26, RPL21, RPS21, RPL7, RPSA |
| 28 | TREM1 signaling | SIGIRR, CXCL8, NLRC3 |
| 29 | Cyclins and cell cycle regulation | PPP2R5D, CDK6, ABL1 |
| 30 | Proline biosynthesis I | ALDH18A1 |
| 31 | l-Cysteine degradation I | GOT2 |
| 32 | Phenylalanine degradation I (Aerobic) | QDPR |
| 33 | Regulation of IL-2 expression in T lymphocytes | CD247, LAT, ZAP70 |
| 34 | Ceramide signaling | SMPD4, S1PR5, PPP2R5D |
| 35 | Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate | GART |
| 36 | dTMP de novo biosynthesis | SHMT2 |
| 37 | Folate polyglutamylation | SHMT2 |
| 38 | Regulation of eIF4 and p70S6K signaling | RPS26, PPP2R5D, RPS21, RPSA |
Abbreviations: IL, interleukin; SLE, stressful life event.
All the 38 pathways obtained from Ingenuity pathway analysis (P-value<0.05) using as input gene set all the 207 genes significantly modulated in subjects exposed to SLEs.