Table 2. Associations with lifespan are age-dependent.

Parent	Age range	Lives	Deaths	Beta	HR	s.e.	P value	Years
Variant rs429358
Father	40–75	73,100	33,393	0.0752	1.0588	0.0212	7.03 × 10−3	−0.30
Father	75+	35,778	24,086	0.1147	1.1216	0.0252	5.34 × 10−6	−0.65
Mother	40–75	75,576	20,780	0.0858	1.0896	0.0268	0.0013	−0.19
Mother	75+	46,365	25,846	0.1847	1.2028	0.0241	1.72 × 10−14	−1.13
Variant rs10519203
Father	40–75	111,025	51,984	0.0924	1.0968	0.0131	1.66 × 10−12	−0.47
Father	75+	53,244	36,139	0.0321	1.0327	0.0158	0.043	−0.16
Mother	40–75	115,003	32,758	0.0565	1.0581	0.0165	6.24 × 10−4	−0.26
Mother	75+	69,620	39,201	0.0292	1.0296	0.0152	0.055	−0.23

P values are given for the discovery analysis of parental allelic dose effect for the sentinel SNP at each locus, separately for maternal and paternal lifespans and younger (40–75) and older (75+) ages. Beta is the effect size from the full Cox model, HR is hazard ratio, years gives the reduction in lifespan in years for a (parental generation) individual carrying one copy of the variant.