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TASK-3 mutants L122D, V136E, and M159W disrupt TCE and isoflurane activation. (A-C) Currents records from FRT monolayers expressing TASK-3 M159W and L122D and their response to TCE or isoflurane. Details of currents records are as described in Fig. 3. (D) Compiled TCE concentration-response for TASK-3 M159W, L122D, and V136E. Wild-type TASK-3 data are from Figs. 3 and 4. Data points for M159W, L122D, and V136E are connected by a straight line.
