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. 2017 May 5;13(5):e1006749. doi: 10.1371/journal.pgen.1006749

Fig 5. Speculative model of gene regulation by RdDM.

Fig 5

(A) In wild-type plants Pol V and AGO4 bind to chromatin and help establish repressive chromatin marks at regulatory regions. These chromatin modifications inhibit chromosomal interactions between genes and distant regulatory regions. (B) When RdDM is not functional, chromosomal interactions are able to occur between promoters and distant regulatory regions bound by transcription factors (orange), thereby affecting gene expression.