Table 4. Association between SCAP polymorphisms and blood pressure stratified by BMI categories in Chinese children.
| SNP | phenotype | BMI categories | Genotype | BP(mmHg) | β | SE | P-value |
|---|---|---|---|---|---|---|---|
| Median(IQR) | |||||||
| rs12487736 (0 = GG, 1 = GA/AA) |
SBP | Normal-weight group | GG | 102(92,112) | 1.84 | 1.01 | 0.069 |
| GA/AA | 104(94,112) | ||||||
| Overweight/obese group | GG | 118(108,126) | 1.6 | 0.68 | 0.019 | ||
| GA/AA | 120(106,130) | ||||||
| DBP | Normal-weight group | GG | 54(44,64) | 2.19 | 1.22 | 0.073 | |
| GA/AA | 56(44,66) | ||||||
| Overweight/obese group | GG | 70(54,80) | 1.01 | 0.68 | 0.136 | ||
| GA/AA | 70(54,80) | ||||||
| rs12490383 (0 = CC, 1 = CT/TT) |
SBP | Normal-weight group | CC | 102(92,112) | 1.03 | 1.06 | 0.336 |
| CT/TT | 104(94,112) | ||||||
| Overweight/obese group | CC | 120(108,126) | 2.04 | 0.72 | 0.004 | ||
| CT/TT | 120(106,130) | ||||||
| DBP | Normal-weight group | CC | 56(44,64.5) | 0.42 | 1.29 | 0.745 | |
| CT/TT | 56(44,66) | ||||||
| Overweight/obese group | CC | 70(54,80) | 0.46 | 0.71 | 0.518 | ||
| CT/TT | 70(54,80) |
Abbreviations: IQR: Inter-Quartile Range. SE: Standard error. BMI: body mass index. SBP/DBP: systolic/diastolic blood pressure. Effect size(β) and P-value were estimated with linear regression analysis under dominant model with age, age-squared, sex, study population and BMI adjusted.