Table 5. Association between SCAP polymorphisms and systolic high blood pressure risk stratified by BMI categories in Chinese children.
SNP | BMI categories | Genotype | Frequency (%) | OR(95%CI) | P-value | |
---|---|---|---|---|---|---|
Non-SHBP | SHBP | |||||
rs12487736 (0 = GG, 1 = GA/AA) |
Normal-weight group | GG | 148(94.27) | 9(5.73) | 0.86(0.37,1.91) | 0.678 |
GA/AA | 424(95.5) | 20(4.5) | ||||
Overweight/obese group | GG | 285(71.79) | 112(28.21) | 1.36(1.02,1.82) | 0.037 | |
GA/AA | 679(67.29) | 330(32.71) | ||||
rs12490383 (0 = CC, 1 = CT/TT) |
Normal-weight group | CC | 124(93.94) | 8(6.06) | 0.76(0.32,1.78) | 0.527 |
CT/TT | 450(95.54) | 21(4.46) | ||||
Overweight/obese group | CC | 246(72.78) | 92(27.22) | 1.50(1.10,2.05) | 0.01 | |
CT/TT | 719(67.13) | 352(32.87) |
Abbreviations: SHBP: systolic high blood pressure. Odds ratio(OR) with 95% confidence interval (CI) and P-value was estimated with logistic regression analysis under dominant model with age, age-squared, sex, study population and BMI adjusted.