Fig 5. Acute PDE4B inhibition reduced cortical contusion volume at 3 days after TBI.

Representative images of the ipsilateral parietal cortex stained with H&E from (A,C) vehicle-treated and (B,D) A33-treated animals at 3 days post-injury. Representative bregma level -6.3 mm. Scale bars (A,B) 1 mm and (C,D) 500 μm. (E) Quantification of contusion volume. Mean ± SEM, n = 10/group, ***p<0.001 vs. TBI+Vehicle, Student’s unpaired t-test.