Fig 5. Saturation phase spaces of PduCDE and PduP/Q (A) with respect to Pout and kc, and (B) with respect to jc and kc.
Regions of saturation (concentration of substrate > KM of the appropriate enzyme) are plotted in blue when PduCDE and PduP/Q are saturated, orange when only PduCDE is saturated, and in grey when neither enzyme is saturated. Red solid lines indicate when Acyto is 1 μM; red dashed lines indicate when Acyto is 10 nM. Black finely dashed lines indicate the baseline parameter values used in the model of the Pdu MCP. The inset to the left in (B) reflects the behavior when jc = 0.