Parameter name	Value	Comment
ε	0.06 mM min−1	Basal H2O2 production rate in the absence of external H2O2 Determined by a fitting procedure to data in Figure 6.
α	1 min−1	H2O2 transport rate across cell membrane. Taken from Figure 1—figure supplement 1C.
β	10 mM−1 min−1	H2O2 scavenging rate. Derived from the absolute adaptation concentration Iabs in Figure 3.
γ	0.1 mM−1 min−1	Antioxidant transcription rate. Derived from the absolute adaptation concentration Iabs in Figure 3.
μ	μ=log(2)/40 min−1	Antioxidant mRNA decay rate. See the linear model above for the determination of parameter value.
γ’	0.005 mM−1 min−1	Antioxidant translation rate. Derived from the absolute adaptation concentration Iabs in Figure 3.
μ’	log(2)/100 min−1	Antioxidant protein decay rate. Tsa1 is a stable protein, therefore, the decay is due to the dilution rate set by cell growth (doubling time ~ 100 min).
K	0.01 mM	Order of magnitude of internal H2O2 at which antioxidant. transcription saturates. Taken from Figure 6—figure supplement 1C.
W	0.01 mM	Order of magnitude of internal H2O2 at which H2O2 scavenging rate saturates. The ratio K/W ~ 1 gave the best fit to curves in Figure 6, hence the order of magnitude of this parameter.