TABLE II.
Quantitative Microsphere Hybridiziation Results for All Subjects
| Probes/location (Hg18) |
19,412,113 |
20,360,015 |
20,402,365 |
20,594,853 |
21,263,422 |
21,402,665 |
21,625,574 |
22,581,253 |
22,682,940 |
22,717,169 |
22,736,900 |
22,751,254 |
22,751,461 |
25,675,102 |
26,017,987 |
26,048,967 |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects | PWS19.4 Mb | D15S541 | GCP5 | NIPA1 | Chr15:21,263,422 | chr15:21,402,665 | D15S11 | D15S63 | D15S128 | AS-SRO | IC1 | SNRPN-exon1 | IC2 | D15S12 | OCA-2 | PWS26.04Mb | Genotype |
| PWS-6 | 0.92 | 0.87 | 1.03 | 0.86 | 0.75 | 0.62 | 0.53 | 0.62 | nt | 0.61 | 0.54 | 0.73 | 0.62 | 0.64 | 0.53 | 0.62 | Type II |
| PWS-10 | 1.00 | 0.97 | 0.80 | 0.80 | 0.40 | 0.59 | 0.46 | 0.67 | nt | 0.47 | 0.40 | 0.67 | 0.65 | nt | 0.56 | 0.71 | Type II |
| PWS-16 | 0.58 | 0.50 | 0.60 | 0.62 | 0.74 | 0.67 | 0.74 | 0.65 | nt | 0.64 | 0.58 | 0.73 | 0.64 | 0.72 | 0.58 | 0.63 | Type I |
| PWS-17 | 0.55 | 0.61 | 0.40 | 0.48 | 0.67 | 0.60 | 0.63 | 0.63 | nt | 0.70 | 0.46 | 0.46 | 0.54 | nt | 0.60 | 0.53 | Type I |
| PWS-18 | 0.47 | 0.45 | 0.62 | 0.52 | 0.41 | 0.49 | 0.40 | 0.56 | 0.58 | 0.47 | 0.50 | 0.62 | 0.48 | 0.91 | 1.02 | 0.98 | Atypical |
| PWS-21 | 0.69 | 0.54 | 1.00 | 1.04 | 0.99 | 1.04 | 0.63 | 0.65 | nt | 0.56 | 0.51 | 0.91 | 1.07 | nt | 0.93 | nt | Atypical |
| PWS-29 | nt | 1.00 | nt | 0.90 | 0.92 | 0.88 | 0.67 | 1.02 | nt | 0.56 | 0.55 | 0.91 | 0.93 | 0.68 | 0.80 | nt | Atypical |
| PWS-26 | nt | 1.30 | nt | 1.37 | 1.20 | 1.50 | nt | 1.57 | nt | 1.25 | 1.20 | 1.59 | 1.73 | nt | 1.31 | 1.52 | Duplication |
| PWS-27 | nt | 1.00 | nt | 1.40 | 1.32 | 1.40 | nt | 1.53 | 1.54 | 1.01 | 1.00 | 1.01 | 1.02 | 0.81 | 0.91 | nt | Duplication |
| PWS-36 | nt | 0.96 | nt | 0.77 | 0.98 | 1.01 | nt | 1.01 | nt | 1.04 | 0.97 | 0.92 | 0.96 | nt | 1.01 | nt | Obese subject |
| PWS-37 | nt | 1.06 | nt | 0.84 | 0.95 | 0.97 | nt | 1.08 | nt | 0.93 | 0.97 | 0.94 | 1.06 | nt | 1.03 | nt | Obese subject |
| PWS-46 | nt | 1.05 | nt | 0.95 | 1.08 | 1.02 | nt | 1.00 | nt | 0.96 | 1.03 | 0.95 | 0.95 | nt | 0.86 | nt | UPD |
| PWS-47 | nt | 0.86 | nt | 0.81 | 1.00 | 0.95 | nt | 1.03 | nt | 1.00 | 0.81 | 1.02 | 1.00 | nt | 0.98 | nt | UPD |
| Control-1 | 1.02 | 0.83 | 1.00 | 1.00 | 0.95 | 1.03 | 0.90 | 1.08 | 1.02 | 0.91 | 0.97 | 1.02 | 0.93 | 0.99 | 0.94 | 0.92 | Normal |
| Control-2 | 0.91 | 0.92 | 1.00 | 1.02 | 1.00 | 1.05 | 0.91 | 0.93 | 0.95 | 1.02 | 0.91 | 0.86 | 0.97 | 0.91 | 0.93 | 0.90 | Normal |
| Control-3 | 1.02 | 0.88 | 1.05 | 1.01 | 0.93 | 0.95 | 1.01 | 0.97 | 0.90 | 0.87 | 0.91 | 0.92 | 0.92 | 1.00 | 1.02 | 0.88 | Normal |
| Control-4 | 1.01 | 1.00 | 0.92 | 1.03 | 1.06 | 1.00 | 0.91 | 0.98 | 0.90 | 0.97 | 0.99 | 0.90 | 1.01 | 0.95 | 0.91 | 0.92 | Normal |
| Control-5 | 0.96 | 0.95 | 1.01 | 0.94 | 0.90 | 1.01 | 0.88 | 1.01 | 0.88 | 1.01 | 0.90 | 1.02 | 1.01 | 0.96 | 0.92 | 0.97 | Normal |
| Control-6 | 0.94 | 0.92 | 1.03 | 0.92 | 0.95 | 1.01 | 0.99 | 1.02 | 0.94 | 1.07 | 1.02 | 0.93 | 1.02 | 0.97 | 0.89 | 1.00 | Normal |
Those regions shaded in light gray represent deleted loci, and those in dark gray represent duplicated loci.
Loci not tested are indicated by “nt.”