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. 2017 May 19;7:2210. doi: 10.1038/s41598-017-02056-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-22 attenuated the ALI induced by AngII. (A) The incidence of lung injury showed remarkable decrease after IL-22 treatment. (B) In the ALI model induced by AngII, obvious oedema was noticed, together with massive infiltration of neutrophils (MPO) and macrophages (CD68), which was significantly reversed after IL-22 treatment. (C) IL22 could significantly attenuate the lung injury as revealed by pathological changes, but such phenomenon was completely reserved after AG490. HE staining and immunohistochemistry images were observed under a magnification of 200× and 400×, respectively. ^*P < 0.05 versus control group. ^#P < 0.05 versus AngII group and AngII+IL-22+AG490 group.