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. 2017 May 19;7:2210. doi: 10.1038/s41598-017-02056-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-22 significantly stimulated nuclear STAT3 expression in PMVECs. (A) STAT3 was mainly localized in the cytoplasm in the control group and AngII group. The expression of STAT3 in the nucleus in the AngII+IL22 group significantly increased, while its expression in the nucleus significantly decreased in the AngII+IL22+AG490 group. (B) Western blot analysis indicated the STAT3 in the nucleus in the AngII+IL22 group was significantly higher than the other groups. The raw data were listed in the Supplementary file. ^*P < 0.05 versus control group; ^#P < 0.05 versus AngII+IL-22+AG490 group.