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. 2017 May 19;7:2213. doi: 10.1038/s41598-017-02316-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compound 8 is a potent Notch signaling inhibitor. Endogenous N1VAL and N3ICD protein expression levels in DND41 T-ALL cells in response to 36 hrs of different doses of exposure to the twelve C-derivative molecules (named 1, 2, 3, 4, 5, 5a, 6a, 7, 7a, 8, 8a and 9). β-actin is used as a loading control. Uncropped Western blots related to this figure are displayed in Fig. S14.