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. 2017 May 19;7:2213. doi: 10.1038/s41598-017-02316-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compound 8 counteracts Notch signaling in T-ALL cell contexts. (a) N1VAL, N3ICD and β-actin protein expression levels in response to 36 hrs of different doses of compound 8 exposures in KOPTK1 and TALL-1. (b) Relative DELTEX1 (DTX1), HES1 and c-MYC gene expression levels in response to 36 hrs of treatment with molecule 8 in KOPTK1, TALL-1 and DND41 cells. In detail, KOPTK1 and DND41 cell were treated with 2.5 μM, while TALL-1 cell with 1 μM of compound 8. Data represent mean values ± S.D. normalized to GAPDH of three independent experiments. *P < 0.05; **P < 0.01; ns not significant. (c) N1VAL and β-actin protein expression levels in response to 36 hrs of dose dependent manner of compound 8 exposures in HaCat cells. Uncropped Western blots related to this figure are displayed in Fig. S15.