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. 2017 May 19;7:2213. doi: 10.1038/s41598-017-02316-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compound 8 impairs cell growth through Notch inhibition. (a) Western blot analysis on GFP-sorted DND41 cells transduced with the mICN1 or with the empty control retroviruses by using antibodies against C-terminal domain of Notch1 and β-actin. (b) Effect of compound 8 treatment on the growth of GFP-sorted DND41 transduced with mICN1 or with the empty retroviruses for the times indicated. The relative cell number in percentage at each time point represents the mean value of triplicates normalized to the cell number at 96 hrs of DMSO treatment. Bars indicate S.D. *P < 0.05; **P < 0.01. Uncropped Western blots related to this figure are displayed in Fig. S17.