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. 2017 May 19;7:2158. doi: 10.1038/s41598-017-02343-6

Figure 1.

Figure 1

Comparison over time of the efficacy of Etomoxir and Escitalopram in chronic mild stress-induced depression. Baseline values indicate sucrose intake after four weeks of stress exposure. Sucrose intake in gram during five weeks of treatment with Escitalopram (n = 14, downwards triangle), Etomoxir (n = 20, square) or vehicle (n = 9, circle) with continuous chronic mild stress exposure. Unchallenged control group was not exposed to the stress protocol but received vehicle treatment (n = 9, triangle). All data are presented as mean ± SEM. The results from the repeated measures two-way ANOVA (interaction F = 2.31, DF = 15, p = 0.0043; time F = 2.21, DF = 5, p = 0.0535; treatment F = 13.63, DF = 3, p < 0.0001) with Tukey multiple comparisons post hoc test showed statistical significance between vehicle and Etomoxir (*), and Escitalopram and Etomoxir (§). Number of asterisks/paragraphs indicates level of statistical significance (*p = 0.01–0.05, **p = 0.001–0.01, ***p = 0.0001–0.001, ****p < 0.0001).