Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Mar 21;57(2):373–386. doi: 10.3233/JAD-160946

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

IOS Press and the authors. All rights reserved

This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0).

PMC Copyright notice

Fig.2 — Analysis of PGPH-like activities in brain homogenates from BA9, BA40, and BA24 of DLB, PDD, AD, and controls. Scatter plots are shown of PGPH-like activity measurement in BA9, BA40, and BA24 homogenates from DLB, PDD, AD, and normal control samples using the fluorogenic substrate assay. Activities are expressed as fluorescence units (FU)/mg protein/hour. BA9: PGPH-like activity was significantly decreased only in AD patients (p = 0.012, n = 6) compared with the control (n = 9); DLB and PDD groups were lower compared with the control subjects, but there was no statistically significant difference between them. The values for the ANOVA for PGPH-like activity measurement in BA9 were: F = 7.897, d.f. = 3, 34, p = 0.001). BA40; the differences between the patients’ groups (PDD, DLB, and AD) and the control were statistically different (one-way ANOVA, F = 10.263, d.f. = 3 and 42, p = 0.001;). The reduction in PGPH-like activity was higher in the AD group with a mean±SEM value of 3741.8±587.5, n = 11, compared with 1.28±0.028, n = 24 for the controls. The reduction in both DLB and PDD were also significant with a mean±SEM value of 4133.7±640, n = 10 and 4809±240, n = 9 compared with control (Bonferroni post hoc test). In BA24, there was a significant difference between DLB (p = 0.013, n = 12), PDD (P = 0.001, n = 9) and AD (P = 0.001, n = 9) compared with the control (n = 13) (one-way ANOVA, F = 23.087, d.f. = 3 and 39, p = 0.001; Bonferroni post hoc test). PGPH-like activity measurements were significant lower in both AD (p = 0.004, n = 9) and PDD (p = 0.002, n = 9) compared with DLB subjects. The horizontal bars within the data points in the graphs represent the mean values. (^**p < 0.01).