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Photomicrographs of postmortem human orbitofrontal cortex from normal (A,D,G), cognitively normal with Aβ plaques (NwAβ, B,E,H), and AD (C,F,I) brains stained for amyloid-β (A,B,C), thioflavin-S (D,E,F), and butyrylcholinesterase (BChE, G,H,I). Note, no BChE staining in normal orbitofrontal cortex (G), paucity of BChE activity associated with NwAβ brain pathology (H), and significant BChE activity in AD (I). Scale bar for all frames (A-I) = 250 μm.
