Fig.2.

Comparisons of percentage area covered by amyloid-β (Aβ; A), thioflavin-S (Th-S; B), or butyrylcholinesterase (BChE; C) pathology in the orbitofrontal cortex, entorhinal cortex, amygdala, and hippocampal formation of normal, cognitively normal with Aβ plaques (NwAβ), and Alzheimer’s disease (AD) brains. A) In AD, significantly greater Aβ was present in the orbitofrontal cortex and amygdala compared to NwAβ brains, whereas the entorhinal cortex and hippocampal formation were not significantly different between AD and NwAβ. B) Th-S pathology occupied considerably less percentage of area in each of the brain regions compared to those stained for Aβ or BChE. However, Th-S pathology burden in AD was significantly greater than NwAβ brains. C) In normal and NwAβ brains, the presence of BChE was negligible. In AD, BChE-associated pathology burden was significantly greater in all regions analyzed when compared to NwAβ, especially in the orbitofrontal cortex with a nearly 9.3-fold increase observed. Significant differences (Bonferroni correction after multiple comparisons) are denoted as follows: ^*p < 0.0167; ^**p < 0.01; ^***p < 0.001; ^****p < 0.0001.