Fig. 6.

MHCSZ-123 inhibited high-shear arterial thrombosis in the Rhesus monkey model. a Representative charts of CFRs showing the effect of MHCSZ-123 on platelet thrombosis induced in the femoral arteries of Rhesus monkeys. Changes in CFRs were recorded from −60 to 60 min. Arrows indicate points at which MHCSZ-123 (0.1, 0.3, and 0.6 mg/kg MHCSZ-123) or saline was administered. b Inhibition of CFRs measured within 1 h after administration of different doses of MHCSZ-123 (0, 0.1, 0.3, and 0.6 mg/kg). c Correlation between MHCSZ-123 dose and inhibition of CFRs. Data represent the mean ± SD (n = 6 animals per group)