Fig. 1.

HDACs in skeletal muscle biopsies and their correlations with clinical parameters. Whole cell proteins were extracted from quadriceps muscle biopsy specimens. HDAC2 protein (a) and HDAC5 protein (b) were measured by sodium dodecyl sulphate polyacrylamide gel electrophoresis/Western blot. Correlations between HDACs in skeletal muscle and clinical parameters were evaluated. FEV₁ %predicted vs HDAC2 protein expression (c), MVC vs HDAC2 protein expression (d), FEV₁ %predicted vs HDAC5 protein expression (e), MVC vs HDAC5 protein expression (f). Abbreviations: healthy non-smokers (NS), smokers without COPD (SM), chronic obstructive pulmonary disease (COPD), histone deacetylase (HDAC), forced expiratory volume in 1 s (FEV ₁); maximum voluntary contraction (MVC)