Table 2.

Correlation between clinical parameters and HDAC2, HDAC5 and NF-κB DNA binding activity in all subjects

	HDAC2	HDAC5	NF-κB
Age	0.04	−0.05	0.01
Pack-year	−0.28	−0.35	0.62**
BMI (kg/m2)	0.36	0.04	−0.03
FEV1%predicted	0.53**	0.64**	−0.54**
FEV1/FVC %	0.55**	0.68**	−0.53**
RV % predicted	−0.33	−0.33	0.59*
KCO % predicted	0.67*	0.03	−0.74*
TLCO% predicted	0.50*	0.43	−0.81**
PaO2	0.32	0.39	−0.54*
PaCO2	−0.16	−0.07	0.30
MVC	0.42*	0.30	−0.50*
NF-κB	−0.59**	−0.50*	NA
HDAC 2 protein	NA	0.63**	−0.59**
HDAC5 protein	0.63**	NA	−0.50*
HDAC1 mRNA	−0.09	−0.02	0.13
HDAC2 mRNA	0.14	−0.11	−0.27
HDAC5 mRNA	−0.36	−0.44	0.12

Abbreviations: BMI body mass index, FEV ₁ forced expiratory volume in 1 s, RV residual volume, KCO carbon monoxide transfer coefficient, TL _CO transfer factor for carbon monoxide in the lung, MVC maximum voluntary contraction, PaO ₂ partial pressure of oxygen in arterial blood, NF-κB nuclear factor-kappa B, HDAC histone deacetylase, NA not applicable

*p < 0.05; ** p < 0.01