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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Nat Immunol. 2017 May 1;18(6):665–674. doi: 10.1038/ni.3746

Fig. 1. Macrophage-restricted Mecp2 deletion causes spontaneous obesity in adulthood.

Fig. 1

(a) Weight of Cx3cr1cre (n=9) and Cx3cr1cre:Mecp2fl/y mice (n=14) over 6 months. *** p<0.001, F20,360=22.24, two- way ANOVA, interaction effect.

(b) Weight of Cx3cr1cre (n=4) and Cx3cr1cre:Mecp2fl/y mice (n=7) kept on high-fat diet (HFD) for 8 weeks starting from 6 weeks of age. *** p<0.001, F8,72=5.871, two- way ANOVA, interaction effect.

(c) Weight of Cx3cr1creER:Mecp2fl/y (n=13) and Cx3cr1creER (n=14) mice over 6 months, all administered TAM at the age of 6 weeks. *** p<0.001, F26, 624=15.57, two- way ANOVA, interaction effect.

(d) Body composition of pre-obese Cx3cr1creER:Mecp2fl/y mice (n=13) and littermate controls (n=4) 6 weeks after TAM treatment (age 12 weeks), and Cx3cr1creER:Mecp2fl/y mice (n=12) and littermate controls (n=5) 12 weeks after TAM treatment (age 18 weeks). *p<0.05, **p<0.01, Mann-Whitney’s U-test.