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. 2017 Feb 6;8(17):27772–27785. doi: 10.18632/oncotarget.15115

Figure 2. The effect of B392 in MOLT-4 and HL60 xenograft models.

Figure 2

SCID mice were ectopically implanted with MOLT-4 cells (A, B) or HL60 cells (C, D). Vincristine 1 mg/kg (i.p.), B392 50 mg/kg or 100 mg/kg (p.o. or i.p.) were treated. (A and C) The curves show the effect of B392 on tumor volume and percentage of tumor growth delay (TGD), which was calculated for treatment groups relative to control group. (B and D) The body weight of mice after indicated drugs treatment. (E) Immunohistochemical staining for the MOLT-4 tumors’ sections. Upper panel is the control, and lower panel is the B392 treatment group. Left panel was stained with hematoxylin and eosin; and right panel with cleavage caspase 3, which represents cells under apoptosis. Each tumor sample is under 160 ×magnification. (F) HL60 xenograft tumour homogenates were used to analyse cleavage caspase 3 protein expressions to determine apoptosis.