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. 2017 Mar 2;8(17):27953–27965. doi: 10.18632/oncotarget.15853

Figure 4. Interference of Aurora kinases contorlled the Hippo pathway and resulted in the accumulation of P21.

Figure 4

(A) The key proteins of Hippo pathway was suppressed due to the knockdown or inhibition of Aurora kinases in HepG2. (B) YAP knockdown induced the accumulation of P21 via WB analysis in SMMC-7721. (C) The accumulation of P21 was induced significantly by SNS-314 treatment with indicated concentrations for 96h in HepG2 and SMMC-7721 cells. (D–E) IHC staining of human HCC tissue array using YAP-specific antibody, as described in Material and Methods. And the classification of samples according to the intensity of staining of YAP expression (n = 138). OS, overall surivival rate; RFS, relapsed free survival rate.