Table 2. Uni- and multivariate analyses of factors associated with survival and recurrence in 138 HCCs.
| Factors | OS | RFS | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate, P | Multivariate | Univariate, P | Multivariate | |||||
| HR | 95% CI | P | HR | 95% CI | P | |||
| Age, Years (< 50 vs. ≥ 50) | 0.99 | NA | 0.675 | NA | ||||
| Child (B vs. A) | 0.286 | NA | 0.047 | 1.951 | 1.063–3.580 | 0.031 | ||
| AFP (< 20 vs. ≥ 20) | 0.215 | NA | 0.425 | NA | ||||
| HBsAg (positive vs. negative) | 0.712 | NA | 0.466 | NA | ||||
| Major tumor size (diameter, cm) | 0.009 | 1.074 | 1.016–1.134 | 0.011 | 0.038 | 1.066 | 1.011–1.124 | 0.018 |
| Number of nodules (< 2 vs. ≥ 2) | 0.172 | NA | 0.452 | NA | ||||
| Satellites nodules (YES vs. NO) | 0.487 | NA | 0.646 | NA | ||||
| MVI (YES vs. NO) | 0.562 | NA | 0.547 | NA | ||||
| HBeAg (positive vs. negative) | 0.057 | NA | 0.078 | NA | ||||
| Aurora A/B | ||||||||
| AHBL/ALBH VS. ALBL | 0.33 | NS | 0.829 | NS | ||||
| AHBH VS. ALBL | < 0.001 | 2.442 | 1.533–3.888 | < 0.001 | 0.011 | 1.753 | 1.108–2.776 | 0.017 |
| YAP (High vs. Low) | 0.001 | 1.533 | 1.059–2.219 | 0.024 | 0.025 | 1.474 | 1.029–2.112 | 0.035 |
| P21 (High vs. Low) | 0.191 | NA | 0.228 | NA | ||||
Cox's proportional hazards regression model.
Abbreviations: OS, overall survival; RFS, relapsed-free survival; NA, not adopted; NS, not significant; YAP, Yes-associated protein; AFP, Alpha Fetal Protein; HBsAg, hepatitis B surface antigen; MVI, Microvascular invasion; HBeAg, hepatitis B e antigen; 95% CI, 95% confidence interval; HR, hazard ratio.