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. 2017 Mar 8;8(17):28226–28236. doi: 10.18632/oncotarget.15999

Figure 6. Effects of overexpression or inhibition of PKM2 on miR-let-7a-inhibited cell proliferation, migration and invasion.

Figure 6

(A) The proliferation capacity of miR-let-7a-overexpressing SiHa and HeLa cells was partially improved when cells were transfected with PKM2 plasmids in comparison with miR-NC. (B, C) The migration and invasion of miR-let-7a-overexpressing SiHa and HeLa cells were effectively improved when cells were transfected with PKM2 plasmids. *P < 0.001, vs. vector. (D) The proliferation capacity of miR-let-7a-overexpressing SiHa and HeLa cells was partially inhibited when cells were transfected with si-PKM2 compared with si-control. (E, F) The migration and invasion of miR-let-7a-overexpressing SiHa and HeLa cells were effectively improved when cells were transfected with si-PKM2. *P < 0.001, vs. si-control.